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Project

Pathways Of Dispersal for Cholera And Solution Tools (PODCAST)

Cholera distribution courtesy of World Health Organization

Completed project

Project start: February 2019  |  Project end: February 2022
Funder: NERC
Principal Investigator: Dr Marie-Fanny Racault
Other participants from PML: Dr James Clark Dr Shubha Sathyendranath Professor Trevor Platt FRS

Image courtesy of the World Health Organization.

Focusing on the northern Indian Ocean, a multidisciplinary team of scientists from India, Japan and the UK will bring together multidisciplinary expertise in remote-sensing, modelling, climate, microbiology, genomic and epidemiology to assess the influence of environmental and climate perturbations on the dynamics and connectivity of Vibrio reservoirs and cholera outbreaks.

Cholera is a waterborne epidemic disease in humans. It is a major public health threat, affecting 1.3 to 4 million people each year worldwide, with 21,000 to 143,000 reported fatalities. In the period 2010-2016, the World Health Organisation (WHO) reported cholera cases in more than 80 countries around the world with 57% of the cases from countries bordering the northern Indian Ocean.

The causative agent of the disease cholera, is the bacterial pathogen Vibrio cholerae, found in many coastal, estuarine, and brackish waters around the world. The disease transmission routes include direct human-to-human infection, and human-to-environment interactions.

In the environment, Vibrio bacteria flourish under warm temperature, moderate salinity and turbidity. They bacteria are found as free-floating forms or attached to living (plankton) and non-living (sediment) hosts, and can be transported through long-distance oceanic corridors by currents, as well as in ballast-waters from ship. To date, despite important efforts in surveillance of cholera epidemics, the major environmental reservoirs of Vibrio bacteria, their connectivity and oceanic transmission routes, their link with climate events, and the associated impact on human health remain largely unknown.

The project PODCAST - Pathways Of Dispersal for Cholera And Solution Tools - funded by the Natural Environment Research Council (NERC) in partnership with Japan Science and Technology Agency (JST) and India’s Department of Biotechnology (DBT), will investigate transmission pathways and produce risk maps for cholera outbreaks to help reduce the threat of this waterborne disease for human health.

PML will lead the PODCAST team to achieve three main objectives:

  1. Improve our understanding of the dynamics and connectivity of environmental reservoirs of Vibrio pathogens and cholera outbreaks in the northern Indian Ocean;
  2. Characterise the influence of climate and extreme weather events on cholera outbreaks and environmental transmission routes;
  3. Advance capability to forecast outbreaks in the northern Indian Ocean RIM countries.

 

Impact

The research will be developed in consultation with end-users, including local communities relying on water resources for livelihoods, income generation and recreation; governments; health services; intergovernmental agencies; and policy makers for whom we will provide tools and cholera risk map products that will support evidence-based policy decisions and actions. The products generated, will be available towards the end of the project in 2022, and will be relevant for further actions towards sustainable human-environment interactions and support achievement of the Sustainable Development Goals on Health (Goal 3), Water Quality (Goal 6), Climate (Goal 13) and Life under the water (Goal 14).